Research progress on the mechanism of the Hedgehog signaling pathway during mandibular development
10.12016/j.issn.2096-1456.202330394
- VernacularTitle:Hedgehog信号通路在下颌骨发育过程中作用机制的研究进展
- Author:
Yao XU
1
;
Wenjin LI
Author Information
1. 山西医科大学口腔医学院·口腔医院,山西 太原(030001)
- Keywords:
Hedgehog signaling pathway;
mandible;
condyle;
intramembranous ossification;
intramembra-nous ossification;
Sonic Hedgehog;
Indian Hedgehog;
mechanism;
abnormal developmentof the mandible;
tem-poromandibular osteoarthritis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(9):709-714
- CountryChina
- Language:Chinese
-
Abstract:
The source and process of mandible development are significantly different from those of other bones in the body,and abnormal development can lead to various bone-related diseases,seriously affecting the quality of life of patients.In recent years,the role of the Hedgehog signaling pathway in bone development has received increasing atten-tion.The Hedgehog gene includes three subtypes:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Shh and Ihh can participate in bone metabolism regulation through various pathways,with Shh primarily involved in limb development and Ihh playing a key role in endochondral osteogenesis.The Hedgehog signaling pathway includes Hedgehog signaling protein ligands,Patched(Ptch)receptors,Smoothed(Smo)receptors,nuclear transcription factors,glioma-associated oncogene homologues(Gli),and downstream target genes.The activation of typical Hedgehog signal-ing pathways requires the involvement of Gli,whereas atypical Hedgehog signaling is mainly regulated by Ptch,Smo,and others.Shh regulates various biological behaviors during early vertebrate embryogenesis,such as organ differentia-tion,neural stem formation,stem cell differentiation and proliferation,limb bone development,and tooth germ develop-ment.During the process of bone cell differentiation,Shh,Ptch1,and Gli1 are expressed in osteoblasts,further promot-ing the differentiation of bone marrow mesenchymal stem cells into osteoblasts and chondrocytes.IHh plays an indis-pensable functional role in bone growth,development,and homeostasis and participates in the formation of intramem-brane bone collars,proliferation,and maturation of chondrocytes.IHh is expressed in mature skull osteoblasts and can act as a promoter of bone factor regulation of Ptch and bone morphogenetic protein(BMP)expression to induce intra-membrane ossification.Brain and muscle ARNT-like protein 1(BMAL1)can regulate the Hedgehog signaling pathway by binding to Ptch1 and Ihh,playing a crucial role in cartilage formation and endochondral osteogenesis in the temporo-mandibular joint.Hedgehog signal activators can improve the reduction in mandibular bone mass caused by BMAL1 de-ficiency.Hedgehog signaling imbalance can have a significant impact on bone development and lead to a series of bone diseases,such as abnormal bone development,fractures,osteoporosis,and osteoarthritis.The mechanism of the Hedge-hog signaling pathway in relation to mandibular diseases has not been fully elucidated,and future research should seek to further explore Hedgehog signaling as a potential target for treating mandibular developmental-related diseases.
- Full text:2024082810104704859Hedgehog信号通路在下颌骨发育过程中作用机制的研究进展.pdf
