Effect of highly purified hMG on ovulation induction in normal ovarian responder patients with antagonist protocol
10.19405/j.cnki.issn1000-1492.2024.06.008
- VernacularTitle:卵巢正常反应人群拮抗剂方案单用高纯度尿促性素促排卵的临床效果
- Author:
Qianhua XU
1
;
Yunxia CAO
;
Juan ZENG
Author Information
1. 安徽医科大学第一附属医院妇产科,合肥 230032;国家卫生健康委配子及生殖道异常研究重点实验室,合肥 230032;出生人口健康教育部重点实验室,合肥 230032;生殖健康与遗传安徽省重点实验室,合肥 230032;安徽省生命资源保存与人工器官工程技术研究中心,合肥 230032
- Keywords:
normal ovarian responder;
HP-hMG;
rFSH;
in vitro fertilization-embryo transfer;
controlled ovulation induction
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):966-970
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences in clinical outcomes of ovulation induction with highly purified human menopausal gonadotropin(HP-hMG,Menopur)versus recombinant human follicle stimulating hormone(rFSH,Gonal-F)in normal ovarian responder patients treated with the GnRH-antagonist protocol.Methods Pa-tients treated with the GnRH-antagonist protocol were retrospectively analyzed and divided by gonadotropin(Gn)usage into HP-hMG group and rFSH group.The basic characteristics,ovulation induction method,laboratory inde-xes,and clinical outcomes were compared between the two groups.Results A total of 614 normal ovarian re-sponder patients were enrolled in the study,with 216 in the HP-hMG group and 398 in the rFSH group.There was no significant difference in P levels and LH levels on the hCG trigger day between the two groups.However,the E2 levels on the hCG trigger day were significantly lower in the HP-hMG group(P＜0.001).Moreover,the HP-hMG group had a higher biochemical pregnancy rate(69.23％vs 63.51％)and clinical pregnancy rate(66.67％vs 59.46％)compared to the rFSH group.The incidence of OHSS in the HP-hMG group(2.31％vs 3.02％)showed a decreasing trend compared to the rFSH group.Conclusion Compared to rFSH,HP-hMG offers distinct advanta-ges in reducing the incidence of OHSS and improving pregnancy outcomes in normal ovarian responder patients un-dergoing pituitary suppression with the GnRH-antagonist protocol.
- Full text:2024081421125931954卵巢正常反应人群拮抗剂方案...度尿促性素促排卵的临床效果_徐千花.pdf
