An investigation on the nutritional status and support of in-patients with common variable immunodeficiency.
10.3760/cma.j.cn112150-20221216-01207
- VernacularTitle:普通变异型免疫缺陷病住院患者的营养状况及支持现状调查
- Author:
Rong Rong LI
1
;
Wei CHEN
1
;
Wei CAO
2
;
Qiang WANG
3
;
Na XU
4
;
Jin Mei LUO
5
;
Ming Sheng MA
6
Author Information
1. Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital, Beijing 100730, China.
2. Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing 100730, China.
3. Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China.
4. Department of General Internal Medicine, Peking Union Medical College Hospital, Beijing 100730, China.
5. Department of Respiratory Diseases, Peking Union Medical College Hospital, Beijing 100730, China.
6. Department of Pediatrics, Peking Union Medical College Hospital, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Child;
Humans;
Female;
Male;
Common Variable Immunodeficiency;
Nutritional Status;
Retrospective Studies;
Cross-Sectional Studies;
Malnutrition
- From:
Chinese Journal of Preventive Medicine
2023;57(12):2164-2170
- CountryChina
- Language:Chinese
-
Abstract:
The study aimed to reveal for the first time the clinical characteristics, nutritional and metabolic status and support of hospitalized patients with common variant immunodeficiency disease (CVID), and provide reference to improve the long-term nutritional management for such patients. This is a retrospective cross-sectional study. Through searching the electronic medical record system of Peking Union Medical College Hospital, the study included 33 consecutive in-patients with CVID diagnosed in Jan 2016 to Jun 2021, with the male to female ratio of 16∶17. All their medical data, nutritional assessment and intervention retrospectively summarized and analyzed. Data with normal distribution were described using (x¯±s), and analyzed with independent sample t-test. Data with non-normal distribution were compared with non-parametric test. The results showed that the median onset-age of the included patients was 22 (10.0,36.5) years old, and the median duration was 9.0 (2.0,16.0) years. All patients had recurrent infections involving various systems (33/33), with development of autoimmune diseases (8/33) and lymphoproliferative disease or malignancy (9/33) in some cases among them. The nutritional risk screening 2002 (NRS 2002) scores revealed that 85.19% of adults had an NRS 2002≥3 points, and 33.33% of children had a BMI-for-age z score<-2. Weight loss occurred in 66.67% of patients (22/33), while 87.88% (29/33), 69.70% (23/33) and 81.82% (27/33) of patients respectively had anemia, hypoalbuminemia and decreased prealbumin. Among 22 patients with micronutrients status evaluated, 77.27% (17/22), 22.73% (5/22) and 31.82% (7/22) of patients respectively had lowered serum iron, folate deficiency and vitamin B12 insufficiency. Six patients underwent 25-OH-VD3 measurement, and were all testified to have vitamin D deficiency. Among all patients with nutritional risk, 56.00% of them underwent nutritional support: oral nutritional supplements (14 cases), enteral feeding (4 cases) and parenteral nutrition (5 cases). In conclusion, the condition of malnutrition was prevalent in patients with CVID, but was under-recognized and undertreated to some degree.
