Research progress on pollen food allergy syndrome.
10.3760/cma.j.cn112150-20230705-00511
- VernacularTitle:花粉-食物过敏综合征研究进展
- Author:
Shuang LIU
1
;
Kai GUAN
1
;
Jia YIN
1
Author Information
1. Department of Allergy, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Child;
Humans;
Rhinitis, Allergic, Seasonal/therapy*;
Syndrome;
Food Hypersensitivity/therapy*;
Pollen;
Fluorocarbons;
Immunoglobulin E
- From:
Chinese Journal of Preventive Medicine
2023;57(9):1336-1341
- CountryChina
- Language:Chinese
-
Abstract:
Pollen food allergy syndrome (PFAS) is an IgE-mediated allergic reaction that occurs when some pollinosis patients ingest certain plant-derived food that contains cross-reactive allergenic components. PFAS is prevalent in both children and adult pollinosis patients. In most cases, PFAS symptoms are confined to the oropharynx and occur within several minutes after oral contact with food. Therefore, PFAS has been also referred as oral allergy syndrome (OAS). A small proportion of PFAS patients would experience systemic symptoms or anaphylaxis. Currently, the diagnosis of PFAS is mainly based on clinical history and allergic tests [skin prick tests and(or) serum specific IgE tests]. Oral provocation tests are used to verify atypical patients. Component-resolved diagnosis is essential for further precise diagnosis and treatment. Management options for PFAS include lifestyle adjustment, symptomatic medication, and immunotherapy. The efficacy and appropriate population for immunotherapy need further investigation. This article aims to update the knowledge on epidemiology, pathogenesis and clinical management of PFAS, thereby enhancing clinicians' understanding as well as treatment progress of this disease entity.
