Low-Dose Baclofen-Induced Encephalopathy in a Patient with End-Stage Renal Disease: A Case Report
- Author:
Chang-Woo KIM
1
;
Jong-Myun LEE
;
Jae-Sang LEE
;
Tae-Hoon DO
;
Hye-Jin MOON
;
Jee-Eun YOON
Author Information
- Publication Type:Case Report
- From:Soonchunhyang Medical Science 2024;30(1):32-35
- CountryRepublic of Korea
- Language:English
- Abstract: Baclofen, a gamma-aminobutyric acid-B receptor agonist, is commonly used for central-origin muscle spasticity and spasm and neuropathic pain. Baclofen toxicity has been reported to cause a range of symptoms including drowsiness, confusion, respiratory depression, seizures, and even coma, particularly with dosage significantly exceeding therapeutic levels. Given that the baclofen is predominantly eliminated through the kidneys, patients with renal failure are at substantial risk for neurotoxic effects. We report a case of baclofen-induced encephalopathy in a patient with end-stage renal disease, characterized by an altered mental state with myoclonus following the consumption of a low dose of baclofen.
