Evaluation of Cellular Responses to ChAdOx1-nCoV-19 and BNT162b2 Vaccinations
10.3343/alm.2023.43.3.290
- Author:
Tae Hwan LEE
1
;
Minjeong NAM
;
Jong Do SEO
;
Hanah KIM
;
Hae-Rim KIM
;
Mina HUR
;
Yeo-Min YUN
;
Hee-Won MOON
Author Information
1. Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea
- Publication Type:Brief Communication
- From:Annals of Laboratory Medicine
2023;43(3):290-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
While numerous studies have evaluated humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, data on the cellular responses to these vaccines remain sparse. We evaluated T cell responses to ChAdOx1-nCoV-19 and BNT162b2 vaccinations using an interferon gamma (IFN-γ) release assay (IGRA). ChAdOx1-nCoV-19- and BNT162b2-vaccinated participants initially showed stronger T cell responses than unvaccinated controls. The T cell response decreased over time and increased substantially after the administration of a BNT162b2 booster dose. Changes in the T cell response were less significant than those in the anti-receptor-binding domain IgG antibody titer. The study results can serve as baseline data for T cell responses after SARS-CoV-2 vaccination and suggest that the IGRA can be useful in monitoring immunogenicity.
