The relationship between miR-146a gene polymorphism and Parkinson’s disease
- VernacularTitle:miR-146a基因多态性与帕金森病的相关性分析
- Author:
Jie ZHAO
1
;
Qiaoyan YU
1
;
Runqing WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease; MicroRNA-146a; Gene polymorphism
- From: Journal of Apoplexy and Nervous Diseases 2020;37(11):999-1003
- CountryChina
- Language:Chinese
- Abstract: Objective To analyze the relationship between single nucleotide polymorphism （SNP） of microRNA-146a （miR-146a） gene and Parkinson’s disease （PD）. Methods In a case-control study，446 patients （PD group） with primary PD were selected from our hospital from October 2015 to August 2019，and 450 healthy people in the health examination center of the same period were selected as the control group，the SNP of rs2910146 and rs5709329 loci in miR-146a were detected by DNA PCR sequencing technology；and the risk factors of PD were analyzed by logistic regression. Results The genotypes of rs2910146 and rs5709329 in miR-146a in PD group and control group were consistent with Hardy-Weinberg equilibrium law （P>0.05）. There was no significant difference in gender，age，BMI and education between PD group and control group （P>0.05）. Compared with the control group，the G allele and GG genotype frequency of rs2910146 locus in PD group were significantly lower （P<0.05）. There was no significant difference in allele frequency and genotype distribution of rs5709329 locus between PD group and control group （P>0.05）. SNP at rs2910146 in miR-146a was related to cognitive dysfunction and age of PD patients （P<0.05），but not to gender，PD subtype and first-onset limb （P>0.05）. Carrying GG genotype was an independent protective factor for PD （P<0.05）.Conclusion SNP at rs2910146 locus in miR-146a is related to age and cognitive impairment in PD patients，and carrying GG genotype may reduce the risk of PD.
- Full text:2024073115275257276miR-146a基因多态性与帕金森病的相关性分析.pdf
