Association of elevated plasma ferritin and triglyceride concentrations in early pregnancy and the risk of gestational diabetes mellitus
10.3969/j.issn.1006-2483.2024.04.037
- VernacularTitle:孕中早期血浆铁蛋白浓度和甘油三酯浓度升高与妊娠期糖尿病风险的相关性
- Author:
Yingchun CHEN
1
;
Ming CHEN
2
;
Minmin WU
1
;
Yilin LI
1
Author Information
1. Department of Medical Laboratory , The Six Hospital of Wuhan , Jianghan University , Wuhan , Hubei 430015 , China
2. Department of Medical Laboratory , The Central Hospital of Wuhan , Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei 430014 , China
- Publication Type:Journal Article
- Keywords:
Ferritin;
Gestational diabetes mellitus;
Mid-pregnancy maternal;
Triglyceride
- From:
Journal of Public Health and Preventive Medicine
2024;35(4):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between combined plasma ferritin and triglyceride (TG) concentrations in early pregnancy and the risk of gestational diabetes mellitus (GDM). Methods A total of 1 000 pregnant women who had antenatal care at the Sixth Hospital of Wuhan from January 2021 to January 2023 were selected as the research subjects. The cut-offs of ferritin and TG were analyzed by using unrestricted cube splines. All participants were divided into 4 groups according to the cut‐off values of ferritin and TG. Associations between combined ferritin and TG concentrations and GDM risk were estimated using multivariable logistic regression models. Results A total of 158 (15.8%) participants were diagnosed with GDM. The ferritin and TG levels in early pregnancy of pregnant women in the GDM group were significantly higher than those in the non-GDM group (P<0.05). After adjusting for potential confounders, the OR for the risk of developing GDM after combining ferritin with TG was 2.35 (1.65, 3.35). Couclusion The increase in plasma ferritin and TG concentrations in early pregnancy is positively correlated with the increased risk of GDM. Pregnant women with high plasma ferritin (˃65.7 ng/mL) and high TG (˃1.9mmoL/L) have the greatest risk of GDM.
