Screening results of colorectal cancer in fecal DNA positive individuals in Wuchang District, Wuhan City in 2021 -2022
10.3969/j.issn.1006-2483.2024.04.025
- VernacularTitle:2021—2022年武汉市武昌地区粪检DNA阳性者结直肠癌筛查结果
- Author:
Danlei YI
1
;
Xia TIAN
2
Author Information
1. School of Medicine，Jianghan University，Wuhan，Hubei 430056，China
2. Department of Gastroenterology，Wuhan Third Hospital，Wuhan，Hubei 430060，China
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Screening;
Fecal DNA testing
- From:
Journal of Public Health and Preventive Medicine
2024;35(4):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the colorectal cancer screening results of people with positive stool DNA tests in Wuchang District, Wuhan City from 2021 to 2022. Methods Based on the Wuhan Free Colorectal Cancer Screening Project, statistical analysis was conducted on the basic information, colonoscopy and pathological reports, and questionnaire survey results of patients who came to Wuhan Third Hospital for colonoscopy review due to positive stool DNA preliminary screening in 2021 to 2022. Result A total of 727 patients completed colonoscopy reexamination, of which lesions were detected in 663 cases. The most polyps with a diameter of <0.5cm were detected, and the polyps located in the sigmoid colon were the most common. The detection rates of overall colorectal lesions, CRC, adenomas, non-adenomatous polyps, chronic colorectal inflammation, and other lesions were 91.20%, 1.51%, 33.15%, 45.94%, 7.98%, and 2.61%, respectively. The overall incidence of colorectal lesions (χ2=8.681, P=0.003) and the detection rate of adenomas in males (χ2=11.289, P =0.001) were higher than those in females, while the detection rate of chronic colorectal inflammation in females was higher than that in males (χ2=4.020, P =0.045). The overall colorectal lesion rate (χ2=4.076, P =0.043) and adenoma detection rate (χ2=4.900, P =0.027) in patients aged 51 to 60 years were higher than those in patients aged 45 to 50 years, and the differences were statistically significant. Age, family history of CRC, smoking, and history of bloody stool/mucinous stool were risk factors for colorectal cancer, and regular physical exercise was a protective factor. Conclusion The screening of colorectal cancer in Wuchang area of Wuhan City from 2021 to 2022 has a high detection rate. It is necessary to strengthen colonoscopy screening for key populations. Timely treatment of early lesions can achieve good results.
