Association between triglyceride-glucose index (TyG) and the risk of new-onset stroke in middle-aged and elderly people

Kui FANG; Jing ZHANG; Chen ZHU; Kun DAI; Liping YU

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Association between triglyceride-glucose index (TyG) and the risk of new-onset stroke in middle-aged and elderly people

VernacularTitle:甘油三酯-葡萄糖指数（TyG）与中老年人新发脑卒中风险的关联研究
Author: Kui FANG ¹ ; Jing ZHANG ² ; Chen ZHU ² ; Kun DAI ³ ; Liping YU ⁴
Author Information

1. School of Nursing , Wuhan University , Wuhan , Hubei 430071, China;Neurosurgery Department , The First Affiliated Hospital of China Medical University , Shenyang 110001, China
2. Neurosurgery Department , The First Affiliated Hospital of China Medical University , Shenyang 110001, China
3. School of Public Health , Wuhan University , Wuhan , Hubei 430071, China
4. School of Nursing , Wuhan University , Wuhan , Hubei 430071, China
Publication Type:Journal Article
Keywords: Triglyceride-glucose index; TyG; Sroke; Correlation study; Dose-response relationship; Charls
From: Journal of Public Health and Preventive Medicine 2024;35(4):37-40
CountryChina
Language:Chinese
Abstract: Objective The high incidence, disability, and mortality rates of stroke result in a heavy economic and social burden. The aim of this study was to investigate the relationship between triglyceride-glucose (TyG) index and new-onset stroke to assist in the identification of high-risk groups for stroke and to provide ideas for effective prevention. Methods The study was based on data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018 and included 7630 eligible middle-aged and elderly participants. The association between TyG index and new-onset stroke was assessed by logistic regression modelling and restricted triple spline analysis. Results A total of 431 participants had a new stroke. The TyG index was found to be a risk factor for stroke occurrence when it was >8.523, and there was a positive linear association moderated by gender. Conclusion Elevated TyG index is a risk factor for new stroke. This study provides new ideas for the identification of high-risk groups for stroke and for intervention measures and timing.