The Pharmaceutical Properties of Sulforaphane and Its Role in Tumor and Neurodegenerative Diseases
10.16476/j.pibb.2022.0545
- VernacularTitle:萝卜硫素的成药性及其在肿瘤和神经退行性疾病中的作用
- Author:
Jian-Le WU
1
;
Xi-Jian LIU
2
;
Ru-Hua LIU
3
;
Feng JIANG
1
;
Dan MIAO
1
Author Information
1. Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, Gannan Medical University, Ganzhou 341000, China
2. School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
3. Ganzhou Pioneer Herb Industrial Co. Ltd., Ganzhou 341100, China
- Publication Type:Journal Article
- Keywords:
sulforaphane;
pharmacokinetic;
signal pathway;
tumor;
neurodegenerative disease
- From:
Progress in Biochemistry and Biophysics
2024;51(1):59-69
- CountryChina
- Language:Chinese
-
Abstract:
Sulforaphane is a naturally occurring active substance derived from cruciferous vegetables with potent antioxidant and anticancer properties. Researches have shown that sulforaphane has good bioavailability and can be absorbed by the small intestine through passive transport, followed by excretion in the form of urine via the hydrophobic acid pathway. In addition, since sulforaphane is easy to be absorbed and metabolized, wrapping sulforaphane with nanomaterials can improve its bioavailability and stability, prolong its action time in human body, and better utilize its therapeutic effect. In terms of mechanism of action, sulforaphane can activate Nrf2 and HSF1 signaling pathways, induce the expression of phase II detoxification enzymes HO-1, NADPH, GST and HSP, thus regulating the concentration of oxidative stress ROS in vivo; inhibit NF-κB signaling pathway, thus suppressing the expression of inflammatory factors TNF-α, IL-1 and IL-6; regulate epigenetic modifications, thus inhibiting HDAC and DNMT, and increasing the concentration of histone H3 and H4. By regulating the expression levels of the above factors, sulforaphane can affect the occurrence and development of cancer, neurodegenerative diseases and other diseases. In recent years, several phase I/II clinical trials have shown that sulforaphane has good drug-generating properties. For example, researchers have found that patients with skin cancer have not shown any health problems and their corresponding functional problems have improved greatly after long-term use of sulforaphane. This suggests that in the future sulforaphane has a very high medicinal potential for the treatment of cancer and neurodegenerative diseases. In this paper, we review the pharmacokinetics, target of action and safety of sulforaphane and its research progress in tumor and neurodegenerative diseases to provide a reference for the future application of sulforaphane in the treatment of tumor and neurodegenerative diseases.
