Role and Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels
10.16476/j.pibb.2023.0032
- VernacularTitle:多不饱和脂肪酸对钾通道的调控作用及机理
- Author:
Yu-Jiao SUN
1
;
Chao CHANG
2
;
Zhen-Hua WU
2
;
Yi-Fei ZHANG
1
;
Yu-Tao TIAN
1
Author Information
1. Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
2. Cardiac Surgery Intensive Care Unit, Chest Hospital, Tianjin University, Tianjin 300051, China
- Publication Type:Journal Article
- Keywords:
polyunsaturated fatty acids;
KV7 channels;
BKCa channels;
lipid molecule;
gating mechanism
- From:
Progress in Biochemistry and Biophysics
2024;51(1):5-19
- CountryChina
- Language:Chinese
-
Abstract:
Polyunsaturated fatty acids (PUFAs) have diverse health-promoting effects, such as potentially protecting in immune, nervous, and cardiovascular systems by targeting a variety of sites, including most ion channels. Voltage-gated potassium channels of the KV7 family and large-conductance Ca2+- and voltage-activated K+ (BKCa) channels are expressed in many tissues, therefore, their physiological importance is evident from the various disorders linked to dysfunctional KV7 channels and BKCa channels. Thus, it is extremely important to learn how potassium channels are regulated by PUFAs. The aim of this review is to provide an overview of the effects of PUFAs on KV7 channels and BKCa channels functions, as well as the mechanisms underlying these effects. In summarizing reported effects of PUFAs on KV7 and BKCa channels mediated currents, we generally conclude that PUFAs increase the current amplitude, meanwhile, differential molecular and biophysical mechanisms are associated with the current increase. In KV7 channels the currents increasement are associated with a shift in the voltage dependence of channel opening and increased maximum conductance in KV7 channels, while in BKCa channels, they are associated with destabilization the pore domain closed conformation. Furthermore, PUFA effects are influenced by auxiliary subunits of KV7 and BKCa channels, associate with channels in certain tissues. although findings are conflicting. A better understanding of how PUFAs regulate KV7 and BKCa channels may offer insight into their physiological regulation and may lead to new therapeutic strategies and approaches.
