Application of Intestinal Organoids in The Study of Intestinal Disease Mechanism
10.16476/j.pibb.2023.0080
- VernacularTitle:肠道类器官在肠疾病机制研究中的运用
- Author:
Long-Zheng QIANG
1
;
Hai-Guang MAO
1
;
Meng-Ting WANG
1
;
Li-Li QI
1
;
Jin-Bo WANG
1
Author Information
1. College of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China
- Publication Type:Journal Article
- Keywords:
intestinal organoids;
intestinal diseases;
pathological mechanism;
drug research and development
- From:
Progress in Biochemistry and Biophysics
2024;51(2):394-403
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal organoids are constructed by crypts or stem cells from the intestine under the 3D support of the culture matrix. They contain all mature cells of the intestine, and have become a new and efficient platform for studying the mechanism of intestinal diseases. Compared with 2D cell culture, organoids can not only more effectively simulate the physiological structure and function of the intestine, but also better restore the true ecology of the intestine in different external environments. Therefore, it is more widely used in the study of pathogenesis of different intestinal diseases. This article reviewed the new progress of intestinal organoids culture, and the application and progress of intestinal organoids in the pathogenesis of inflammatory bowel diseases, colorectal cancer and celiac disease in recent years, and also discussed the application of intestinal organoids in drug research and development and screening.
