Association between endometrial cancer and breast cancer: a bidirectional Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2024.04.017
- Author:
LIANG Wei
;
GONG Xin
;
ZHANG Xiaoxiao
;
LI Shumiao
- Publication Type:Journal Article
- Keywords:
breast cancer;
endometrial cancer;
Mendelian randomization;
causal relationship
- From:
Journal of Preventive Medicine
2024;36(4):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the causal relationship between endometrial cancer and breast cancer using bidirectional two-sample Mendelian randomization (MR) approach.
Methods:Genetic association data of endometrial cancer were collected through a meta analysis, including 54 884 participants and 9 464 330 single nucleotide polymorphisms (SNPs), and genetic association data of breast cancer were collected through the Breast Cancer Society Consortium, with 228 951 participants and 10 680 257 SNPs. A forward MR analysis was performed using the inverse variance weighted (IVW) method with 8 endometrial cancer-associated SNPs as instrumental variables and breast cancer as the study outcome, and a reverse MR analysis was performed with 112 breast cancer-associated SNPs as instrumental variables and endometrial cancer as the study outcome. The heterogeneity was assessed using the Cochran's Q test, the horizontal pleiotropy was assessed using the MR-PRESSO test and MR-Egger regression, and the robustness of the results was verified with the leave-one-out.
Results:Forward MR analysis results showed that patients with genetically predicted endometrial cancer had an increased risk of breast cancer compared to those without endometrial cancer (OR=1.083, 95%CI: 1.037-1.132). Reverse MR analysis showed that patients with genetically predicted breast cancer had an increased risk of endometrial cancer compared to those without breast cancer (OR=1.070, 95%CI: 1.010-1.134). Cochran's Q test detected no heterogeneity (P>0.05), and neither the MR-PRESSO test nor the MR-Egger regression revealed horizontal pleiotropy of instrumental variables (both P>0.05). Leave-one-out analysis showed robustness of the MR analysis results.
Conclusion:There are bidirectional causal relationship between endometrial cancer and breast cancer.
- Full text:2024072409274859599子宫内膜癌与乳腺癌的双向孟德尔随机化研究.pdf
