Correlation between serum galectin-3,MMP-9 expression and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke
- VernacularTitle:血清Galectin-3、MMP-9表达与急性缺血性脑卒中患者静脉溶栓治疗后神经功能缺损的相关性
- Author:
Xin XIE
1
;
Xinping ZHOU
1
;
Jin FAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Acute ischemic stroke; Intravenous thrombolysis; Galectin-3; Matrix metalloproteinase-9; Neurological deficit
- From: Journal of Apoplexy and Nervous Diseases 2022;39(8):719-722
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between the expression of serum galectin-3 and matrix metalloproteinase-9 (MMP-9) and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke (AIS).Methods The clinical data of 100 patients with AIS who received intravenous thrombolytic therapy in the hospital were retrospectively analyzed.The neurological deficit （NIHSS） of all patients after thrombolytic therapy was evaluated.They were divided into severe group (NIHSS score≥15，71 patients) and mild to moderate group (NIHSS score 0~14，29 patients),and the relationship between the levels of serum galectin-3 and MMP-9 and the neurological deficit after intravenous thrombolytic therapy of AIS patients was analyzed.Results The serum galectin-3 and MMP-9 levels of severe group high than mild to moderate group (P<0.05).The high expression of serum galectin-3 and MMP-9 before thrombolysis may be the risk factors of severe neurological deficit after thrombolysis in AIS patients （OR=1.385、1.166，P<0.001、=0.002，95%CI1.160~1.653、1.060~1.282）.Besides,they can predict the risk of severe neurological deficit in patients with AIS after thrombolytic therapy (AUC=0.781、0.718).Conclusion The levels of serum galectin-3 and MMP-9 in patients with AIS before thrombolysis are related to the neurological deficit after thrombolysis.Their overexpression may increase the risk of severe neurological deficit.
- Full text:2024072322504811830Correlation between serum galectin-3,MMP-9 expression and neurological deficit after intravenous thrombolysis in patients with acute ischemic stroke.pdf
