Analysis of influencing factors of fatigue in Parkinson’s disease
- VernacularTitle:帕金森病伴发疲劳的影响因素分析
- Author:
Caixia FENG
1
;
Ping SHI
1
;
Lan WU
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson’s disease; Fatigue; Gauge; Motor symptoms; Depressed; Anxious; Postural abnormalities-gait disorders
- From: Journal of Apoplexy and Nervous Diseases 2022;39(9):799-802
- CountryChina
- Language:Chinese
- Abstract: To analyze the influencing factors and clinical significance of fatigue in patients with Parkinson’s disease（PD）. Methods 155 patients with PD were selected from the Department of Neurology of the Second Affiliated Hospital of Baotou Medical College from January 2019 to December 2020.According to the fatigue severity scale（FSS），59 patients in the PD non fatigue group（FSS>4 points） and 96 patients in the PD fatigue group（FSS≤4 points）. Unified Parkinson’s disease rating scale Part III（MDS-UPDRS Ⅲ）、Hoehn-Yahr（H-Y）、Hamilton Depression Scale（HAMA）17，Hamilton Anxiety Scale（HAMD）14,Parkinson’s disease Sleep Scale（PDSS） Chinese version，simple mental state scale and so on. The physical fatigue and mental fatigue of PD patients were scored by fatigue Scale-14（fs-14）. The total scores of tremor items and postural abnormalities gait disorders were calculated according to the items of MDS UPDRS Ⅱ～Ⅲ. Results Compared with the non fatigue group，the mds-updrs Ⅲ，H-Y score，HAMA，HAMD and course of disease in the fatigue group were increased，and the PDSS was decreased（P<0.05）. Mds-updrs Ⅲ score（OR=1.105，P=0.011） and depression（OR=1.160，P=0.028） were independent risk factors for fatigue. Mental fatigue was positively and strongly correlated with HAMD（rs=0.792）；physical fatigue was positively and strongly correlated with mds-updrs Ⅲ（rs=0.645），total score of postural abnormalities gait disorders（rs=0.659），HAMA（rs=0.654） and H-Y score（rs=0.674），which was positively and strongly correlated with PDSS（rs=-0.674） negative strong correlation. Conclusion The incidence rate of fatigue in PD patients is high，and is associated with motor symptoms，sleep disorders，anxiety and depression.
- Full text:2024072322020502690帕金森病伴发疲劳的影响因素分析.pdf
