Research progress of melatonin in regulating angiogenesis in fundus diseases
10.3980/j.issn.1672-5123.2024.8.08
- VernacularTitle:褪黑素调节血管生成在眼底疾病中的研究进展
- Author:
Lingqi YANG
1
;
Jianfeng LI
1
;
Yang LYU
1
Author Information
1. Ophthalmic Center, the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China; First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; Basic Medical Laboratory, the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army;Laboratory of Stem Cell and Gene Medicine of Gansu Province, Lanzhou 730050, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
diabetic retinopathy;
central serous chorioretinopathy;
melatonin;
angiogenesis
- From:
International Eye Science
2024;24(8):1223-1228
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is a key step involving physiological and pathological processes, and pro/antiangiogenic factors are involved in angiogenesis throughout. Melatonin is a product synthesized by the pineal gland of the human brain and acts in various systems of the body. This article briefly describes the wide range of biological roles and physiological functions of melatonin, and summarizes that melatonin regulates pro-/anti-angiogenic factors(e.g., vascular endothelial growth factor/matrix metalloproteinase)under different conditions and is involved in angiogenesis in fundus diseases(e.g., age-related macular degeneration, diabetic retinopathy, and central serous choroioretinopathy); in addition, it also summarizes that melatonin regulates various cytokines, inflammatory factors and signaling pathways to produce anti-inflammatory, antioxidant and immune responses in fundus diseases, and thus obtaining the application and potential treatment of melatonin in fundus vascular diseases, with a view to providing new ideas and therapeutic targets for the treatment of fundus diseases.
