Preparation and performance of an adhesive hemostatic dual-network hydrogel
10.19405/j.cnki.issn1000-1492.2023.02.012
- Author:
Yufan Ding
1
;
Rui Su
2
;
Zhao Pan
3
;
Huiqin Wen
1
Author Information
1. Dept of Blood Transfusion，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
2. Dept of Blood Transfusion，The First Affiliated Hospital of Anhui Medical University，Hefei 230022 Dept of Blood Transfusion，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
3. Institute of Basic Medicine and Cancer，Chinese Academy of Sciences，Hangzhou 310022
- Publication Type:Journal Article
- Keywords:
methacryloxyethyltrimethyl ammonium chloride;
acrylamide;
gelatin;
dual-network hydrogel;
synergistic physical hemostasis and chemical hemostasis
- From:
Acta Universitatis Medicinalis Anhui
2023;58(2):243-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare an adhesive hemostatic hydrogel and examine its hemostatic performance and biocompatibility．
Methods:The precursor components were homogenously dissolved and photo-crosslinked in order to form dual-network hydrogel．The electron microscopy morphology was then analyzed ; mechanical properties were tested ; in vitro hemostatic performances were investigated by whole blood clotting test and simulation trial of cutaneous bleeding．Further，the hemocompatibility was evaluated.
Results:A characteristic porous network structure was presented through microscopy observation of the sample．The tensile strength of hydrogel reached 46 kPa，and strong adhesion was achieved between the hydrogel and ex vivo biological tissues．Hydrogel had significant effect on wound closure and clotting time could be shortened to 1 minute．
Conclusion:The hydrogel was capable of accelerating coagulation due to its ability to accumulate platelets and red cells after blood contact．The dual-network hydrogel with good hemocompatibility enabled excellent hemostatic performance by the synergistic effects of the chemical activation mechanism and physical hemostatic effect.
- Full text:2024071421233675190一种黏性止血双网络水凝胶的制备及性能评估_丁宇帆.pdf
