Mechanism of Biochanin A in treating gliomas based on network pharmacology and molecular docking
10.3969/j.issn.1673-9701.2024.05.001
- VernacularTitle:基于网络药理学和分子对接技术探讨鹰嘴豆芽素A治疗神经胶质瘤的作用机制
- Author:
Dongping WANG
1
;
Wanwen GE
2
;
Guoqiang YUAN
3
Author Information
1. School of traditional Chinese and Western Medicine, Gansu University of Chinese Medicine; Department of Clinical Teaching, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China
2. Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou 730030, Gansu, China
3. Key Laboratory of Neurology, Gansu Province, Lanzhou 730030, Gansu, China
- Publication Type:Journal Article
- Keywords:
Biochanin A;
Gliomas;
Network pharmacology;
Molecular docking
- From:
China Modern Doctor
2024;62(5):1-5,19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the mechanism of Biochanin A in the treatment of Gliomas based on network pharmacology and molecular docking.Methods Traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),TargetNet,Swiss Target Prediction were used to search the active components and targets of Biochanin A.DisGeNET,GeneCards databases were used to search the corresponding targets of Gliomas.The intersection of active components of Biochanin A and gliomas target were selected to obtain the potential target of Biochanin A in treating Gliomas.Protein gene interaction data were obtained by STRING database,and protein-protein interaction network was constructed by importing into Cytoscape software.Gene ontology(GO)function and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis of the same target proteins of drug and disease were carried out by DAVID database.Molecular docking was performed by using DockThor and Pymol software.Results A total of 149 targets of Biochanin A,5654 gliomas relate-genes,97 common targets of Biochanin A and gliomas are collected.The key targets were epidermal growth factor receptor(EGFR),estrogen receptor(ESR1),heat shock protein(HSP)90AA1,matrix metalloproteinase(MMP)9,PPARG and PTGS2.The targets were mainly play an essential role in cell proliferation,invasion,cell apoptosis,and other biological pathways.GO enrichment analysis demonstrated that Biochanin A could involve the treatment of Gliomas in biological process,cell composition and molecular function.KEGG 108 signaling pathways mainly related to pathways in cancer,chemical carcinogenesis-receptor activation,Lipid and atherosclerosis,PI3K/Akt pathway.Molecular docking indicated that Biochanin A had a good bonding activity with the key targets.Conclusion Biochanin A may play a role in the treatment of glioma by inhibiting tumor cell proliferation,inducing apoptosis and enhancing chemotherapy sensitivity.The study built a foundation for drug development and innovative research.
