Correlation analysis between serum vitamin D level and central precocious puberty in girls
10.3969/j.issn.1673-9701.2024.03.005
- VernacularTitle:血清维生素D水平与女童中枢性性早熟的相关性分析
- Author:
Yongzheng LOU
1
;
Yanan XU
2
;
Pingping ZHANG
3
;
Jiewen PAN
4
;
Dongmei GAN
5
;
Shuni SUN
6
Author Information
1. NICU, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
2. Scientific Research Department, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
3. Pediatric Endocrinology Department, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
4. Central Laboratory of Birth Defects Prevention and Control, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
5. Emergency Department, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
6. Pediatric Cardiology Department, Ningbo Women and Children’s Hospital, Ningbo 315012, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Central precocious puberty;
Girl;
Vitamin D
- From:
China Modern Doctor
2024;62(3):16-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum vitamin D level and central precocious puberty(CPP)in girls.Methods A total of 103 girls(case group)with central precocious puberty from Ningbo Woman and Children's Hospital and 53 healthy girls(control group)from health check-ups in Ningbo Women and Children's Hospital were collected as subjects.The serum levels of 25-hydroxyvitamin D3[25(OH)D3]in the two groups were detected by chemiluminescence method.The weight and height of girls in the case group were measured.The serum levels of follicle-stimulating hormone(FSH)and its peak value,luteinizing hormone(LH)and its peak value,estradiol(E2),prolactin(PRL),human chorionic gonadotropin(HCG)and thyroid function were measured by radioimmunoassay.The peak value of LH/FSH was calculated.B ultrasound examination of uterine adnexa was completed to calculate uterine volume and bilateral ovarian volume.According to the results of serum 25-(OH)D3,girls in the case group were divided into normal vitamin D group and vitamin D deficiency group,and the differences of hormone levels,uterine and ovarian development between the two groups were compared.Results The serum level of 25-(OH)D3 in case group was lower than that in control group,and the vitamin D deficiency rate in case group was higher than that in control group,with statistical significance(P<0.05).The age of breast nodules in vitamin D deficiency group was lower than that in vitamin D normal group(P<0.05).There were no significant differences in body weight,height,body mass index(BMI),uterine volume and left ovarian volume between vitamin D normal group and vitamin D deficiency group(P>0.05),and the right ovarian volume in vitamin D deficiency group was significantly higher than that in vitamin D normal group(P<0.05).There were no significant differences in serum levels of FSH,LH,PRL,HCG,peak value of FSH and thyroid function between normal and deficient groups(P>0.05).The levels of E2,LH and LH/FSH in vitamin D deficiency group were significantly higher than those in vitamin D normal group(P<0.05);25-(OH)D3 was negatively correlated with LH/FSH peak(r=-0.197,P<0.05),but was not significantly correlated with thyroid function,FSH,LH,PRL,E2,HCG,FSH and LH peak(P>0.05).Conclusion Vitamin D deficiency is associated with central precocious puberty in girls.Vitamin D deficiency may lead to early onset of precocious puberty.Vitamin D deficiency may affect the hypothalamic-pituitary-gonadal axis function,resulting in changes in reproductive hormone indexes and consequent increase in ovarian volume in girls.
