Study on the value of diamine oxidase in the evalution of ulcerative colitis
10.3969/j.issn.1673-9701.2023.34.009
- VernacularTitle:二胺氧化酶对溃疡性结肠炎病情评估的价值研究
- Author:
Jianjun TONG
1
;
Jianbo XUE
;
Hongqiao LIU
;
Lei ZHANG
Author Information
1. 首都医科大学大兴医院消化科,北京 102600
- Keywords:
Diamine oxidase;
Ulcerative colitis;
Intestinal mucosal barrier;
Disease assessment
- From:
China Modern Doctor
2023;61(34):34-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of peripheral blood diamine oxidase(DAO)in evaluating the severity of ulcerative colitis(UC).Methods A total of 76 UC patients admitted to Daxing Hospital,Capital Medical University from June 2020 to June 2022 were included in UC group,and were divided into severe ulcerative colitis(SUC)group and non-SUC group according to the severity of the disease.A total of 76 healthy subjects were included as control group.The general data and serum DAO of all subjects were collected for statistical analysis.Results The serum DAO level in UC group was significantly higher than that in control group(P<0.05).The serum DAO level in SUC group was significantly higher than that in non-SUC group(P<0.05).Receiver operating characteristic curve analysis showed that DAO predicted area under the curve(AUC)of UC was 0.751(95%CI:0.672-0.829,P<0.001),and DAO predicted AUC of SUC was 0.866(95%CI:0.807-0.925,P<0.001).Conclusion Serum DAO is an effective test index for evaluating the severity of UC,which is worthy of clinical promotion.
