Effect of tripterysium glycosides tablets on the pharmacokinetics of valsartan in rats
- VernacularTitle:雷公藤多苷片对缬沙坦在大鼠体内药代动力学的影响
- Author:
Jun ZHAO
1
;
Ye XU
;
Yanbo SHI
;
Ke HUANG
;
Liyong WANG
Author Information
1. 浙江省嘉兴市中医医院肾内科
- Keywords:
Valsartan;
Tripterysium glycosides tablets;
Pharmacokinetics;
Drug interactions
- From:
China Modern Doctor
2018;56(14):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of tripterysium glycosides tablets on the pharmacokinetics of valsartan in rats combined with tripterysium glycosides tablets and valsartan. Methods 16 male Sprague-Dawley rats were randomly divided into two groups: the single administration group and the combined administration group. In the single administration group, the rats were given intragastric administration of valsartan (20 mg/kg) and the combined administered group was given intragastric administration of tripterysium glycosides tablets (10 mg/kg) and valsartan (20 mg/kg). Blood samples were taken at different time points and plasma concentrations of valsartan were determined by LC-MS. Pharma-cokinetic parameters were calculated. Results The maximum plasma concentration of valsartan was [(1. 57 ±0. 32) vs(1. 01±0. 28)μg/mL] and the plasma area under the curve was [(10. 01 ±0. 58) vs (6. 82±0. 77)mg·h/L], which were signifi- cantly increased in the combined administration group combined with the single administration group (P＜0. 05), indicating that valsartan metabolism was significantly inhibited. Conclusion Tripterysium glycosides tablets combined with valsartan has a significant effect on the pharmacokinetics of valsartan. This study plays a guiding role in the combined administration of valsartan and tripterygium glycosides tablets, which can avoid the occurrence of clinical adverse drug interactions.
