The changes and clinical significance of serum high mobility group box-1 protein level of children's patients with acute traumatic brain injury
- VernacularTitle:急性颅脑损伤患儿血清HMGB1的变化及其临床意义
- Author:
Linxia WANG
1
;
Luming TANG
;
Min WANG
;
Chunxue YAN
;
Guoquan PAN
Author Information
1. 温州医科大学附属第二医院儿童ICU
- Keywords:
Acute traumatic brain injury;
High mobility group box-1 protein;
Children patients;
Sepsis;
Acute lung injury
- From:
China Modern Doctor
2015;(22):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum high mobility group box-1 protein level of children's patients with a-cute traumatic brain injury and it's expression changes and clinical significance. Methods A total of 87 children's patients with acute traumatic brain injury were randomly divided into three groups: severe group (≤8 scores), moderate group(9 to 12 scores) and minor group(13 to 15 scores) according to the patients' Glasgow Coma Scale on admission. Their venous blood were drawn at 3 h, 6 h, 12 h, 24 h, 48 h after injury and the serum HMGB1 were determined by en zyme linked immunosorbent assay(ELISA). The serum HMGB1 concentration were compared between different groups, survivors and non-survivors in 28 days, patients who developed acute lung injury(ALI) or sepsis and who did not deve-lope ALI or sepsis in severe injury group. Results Compared with the minor and moderate group, the serum HMGB1 level in severe group were significantly elevated at each time points(P<0.01). At 6 h, 12 h, 24 h, 48 h time points, the serum HMGB1 level in the moderate group increased significantly compared with the minor group (P<0.01). The serum HMGB1 levels at 24 h after injury were higher in non-survivors compared with survivors (P<0.01). The serum HMGB1 levels in those patients who developed acute lung injury (ALI) or sepsis were higher than who did not develope ALI or sepsis (P<0.01). Conclusion The serum HMGB1 concentration is increased early and may be a ‘alarm signal'prog-nosticating prognosis and complication after acute traumatic brain injury in children.
