The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach.
- Author:
Hyun Jin JO
1
;
Nayoung KIM
;
Ryoung Hee NAM
;
Hyun CHANG
;
Joo Hyon KIM
;
Ji Hyun PARK
;
Jung Mook KANG
;
Dong Ho LEE
;
Hyun Chae JUNG
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. nayoungkim49@empas.com
- Publication Type:Original Article
- Keywords:
Gastric acid;
Hydrogen-potassium-activated ATPase;
Cochinchina momordica seed;
Aging;
Connective tissue
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
Aged;
Aging;
Animals;
Connective Tissue;
Gastric Acid;
Humans;
Male;
Momordica;
Mucous Membrane;
Preschool Child;
Rats;
Rats, Inbred F344;
RNA, Messenger;
Seeds;
Stomach
- From:Gut and Liver
2013;7(5):560-568
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Cochinchina momordica seed extract (SK-MS10) has a gastric protective effect. We aimed to assess the effect of SK-MS10 on gastric acid secretion with morphologic changes in the aged rat. METHODS: Acid secretions were evaluated in the male F344 rats of four different ages (6-, 31-, 74-week, and 2-year). The 31-week-old rats were divided to three groups and continuously administered chow containing vehicle, SK-MS10 and lansoprazole, respectively. At the age of 74 weeks and 2 years, basal and stimulated acid was measured and the expression of mRNA and protein of H(+)-K(+)-ATPase were determined. The area of connective tissue of lamina propria was measured. RESULTS: Basal and stimulated gastric acid significantly decreased and connective tissue of lamina propria increased with age. The expression of mRNA and protein of H(+)-K(+)-ATPase significantly decreased with age. However, 74-week-old rats in the SK-MS10 group had higher stimulated gastric acid secretion than those in the vehicle and lansoprazole groups. In 2-year-old rats of SK-MS10 group, there was no increase of connective tissue. CONCLUSIONS: As SK-MS10 kept the capacity of acid secretion as well as connective tissue area to comparable to young rats, it might valuable to perform further research regarding mechanism of SK-MS10 as an antiaging agent in the stomach.
