Changes of serum sTREM-1, NF-κB and IL-8 levels in senile patients with hospital-acquired pneumonia
- VernacularTitle:老年患者医院获得性肺炎血清可溶性髓系细胞触发受体-1、核转录因子-κB和白细胞介素-8水平变化的研究
- Author:
Yanrui WANG
1
;
Zhimin ZHANG
;
Yu CHEN
;
Zhongqiang TENG
;
Lingling FU
;
Juan LIN
Author Information
1. 福建卫生职业技术学院附属医院 福建省级机关医院呼吸科
- Keywords:
Hospital-acquired pneumonia;
Soluble triggering receptor expressed on myeloid cell-1;
Nuclear factor-κB;
Interleukin-8
- From:
China Modern Doctor
2014;(29):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of soluble triggering receptor expressed on myeloid cell-1 (sTREM-1)and inflammatory mediators in serum of senile patients with hospital-acquired pneumonia and explored the state of local inflammatory response in HAP. Methods Twenty senile patients with HAP and twenty healthy controls were in-cluded. Serum sTREM-1, nuclear factor-κB (NF-κB) and interleukin-8 (IL-8) were detected on day 1, 5, 10. Com-bined with CPIS score to analyze the correlation of these indicators and the severity and prognosis of pneumonia. Re-sults The concentrations of sTREM-1, NF-κB and IL-8 in serum were significantly higher than those in controls. There was a significant positive correlation between the sTREM-1, NF-κB and IL-8 and CPIS score. Conclusion sTREM-1, NF-κB and IL-8 is a good marker in diagnosing pneumonia. The levels of sTREM-1, NF-κB and IL-8 have a positive correlation with severity of HAP.
