Effect of trihalomethanes on germ cells and brood size of Caenorhabditis elegans
10.19405/j.cnki.issn1000-1492.2023.01.002
- Author:
Jiajie Wu
1
;
Tong Zhou
2
;
Zhenxiao Cao
2
;
Yu Feng
2
;
An Xu
2
;
Hua Du
3
Author Information
1. High Magnetic Field Key Laboratory, Hefei Institutes ofPhysical Science ,Chinese Academy ofSciences ,Hefei 230031 ; Science Island Branch of Graduate School , University of Science and Technology of China , Hefei 230026
2. High Magnetic Field Key Laboratory, Hefei Institutes ofPhysical Science ,Chinese Academy ofSciences ,Hefei 230031 ;Science Island Branch of Graduate School , University of Science and Technology of China , Hefei 230026
3. High Magnetic Field Key Laboratory, Hefei Institutes ofPhysical Science ,Chinese Academy ofSciences ,Hefei 230031 ; Science Island Branch of Graduate School , University of Science and Technology of China , Hefei 230026
- Publication Type:Journal Article
- Keywords:
disinfection by⁃products;
Caenorhabditis elegans;
germ cell apoptosis;
number of oocytes;
brood size
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):5-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the effects of 3 types of trihalomethanes ( THMs) , the by⁃products in treatment of drinking water disinfection , on the development and reproductive capacity of germ cells of Caenorhabditis
elegans.
Methods :Tribromomethane ( TBM) , trichloromethane ( TCM) and triiodomethane ( TIM) , 3 types of THMs were selected and wild type Caenorhabditis elegans was used as a model to detect germ cell apoptosis , oocyte number and the final brood size after exposure to different concentrations of THMs.
Results :The results of germ cell apoptosis showed that the exposure to 50 μmol/L TCM and TIM caused elevated levels of germ cell apoptosis in a dose⁃dependent manner. Oocyte counting results showed that exposure to 50 μmol/L all three THMs significantly reduced the number of oocytes. The brood size results showed that only 50 μmol/L TIM exposure significantly de⁃
creased the brood size of nematodes.
Conclusion :THMs showed negative impacts on the reproductive system of Caenorhabditis elegans , and the toxicity is related to the halogenated elements of THMs.
- Full text:2024070320565411225三卤甲烷对秀丽隐杆线虫生殖细胞及子代数的影响_吴佳洁.pdf
