Recent advance in role of cerebral microvascular lesions in type 2 diabetes mellitus-associated cognitive impairment
10.3760/cma.j.cn115354-20230803-00043
- VernacularTitle:脑微血管病变在2型糖尿病认知障碍中的作用研究进展
- Author:
Limin LIU
1
;
Jiayuan CHEN
;
Jing XIONG
Author Information
1. 昆明医科大学第二附属医院神经内科，昆明 650031
- Keywords:
Cerebral microvascular lesion;
Type 2 diabetes mellitus;
Cognitive impairment;
Blood-brain barrier injury;
Biomarker
- From:
Chinese Journal of Neuromedicine
2024;23(1):83-88
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is a common clinical complication in type 2 diabetes (T2DM). T2DM-related cognitive impairment has complex and multifactorial pathogenesis. Cerebral microvascular dysfunction is an important pathological change in patients with T2DM and pre-T2DM, and it can induce blood-brain barrier injury and impaired blood perfusion regulation, with disturbed neurovascular coupling and cerebral autoregulation, leading cognitive impairment. This article reviews the epidemiology and pathophysiological mechanisms related to T2DM cerebral microvascular lesions and cognitive impairment, and how to monitor changes of cerebral microvascular structure and function so as to provide new approach for diagnosis and treatment of T2DM-related cognitive impairment.
