Recent advance in role of gut microbiota in Alzheimer's disease
10.3760/cma.j.cn115354-20230702-00364
- VernacularTitle:肠道微生物群在阿尔茨海默病中的作用研究进展
- Author:
Junyi LIANG
1
;
Bin LIU
;
Xiaohong DONG
;
Wenhui CAI
;
Ning ZHANG
;
Hong ZHANG
Author Information
1. 黑龙江中医药大学基础医学院，哈尔滨 150040
- Keywords:
Gut Microbiota;
Alzheimer's disease;
Gut-brain axis mechanism;
Gut microbial metabolity;
Neuroimmunity
- From:
Chinese Journal of Neuromedicine
2023;22(12):1287-1292
- CountryChina
- Language:Chinese
-
Abstract:
Gut microbiome is an important part of the human gut, which is closely related to human health and disease. Alzheimer's disease (AD) is a kind of neurodegenerative diseases, and its underlying pathogenesis has not been fully elucidated. In recent years, studies have shown obvious differences in gut microbiome composition between AD patients and healthy subjects. Comprehensive changes in gut microbiota composition may play a role in AD progression through the gut-brain axis. However, the mechanism of this interlinkage is not yet fully understood. In this review, we explore the mechanism of gut microbiota's influence in AD through gut-brain axis regulation.
