Recent advance in pathogenesis of high altitude depression based on hypoxia-inducible factors
10.3760/cma.j.cn115354-20221116-00836
- VernacularTitle:基于缺氧诱导因子探讨高原抑郁症发病机制的研究进展
- Author:
Xiaofeng LI
1
;
Zhaojun ZHANG
;
Minxia ZHU
Author Information
1. 西藏民族大学医学院高原低氧环境与生命健康实验室，咸阳 712082
- Keywords:
Hypoxia-inducible factor;
Depression;
Hypoxia;
Neurotrophic factor;
Energy metabolism;
5-hydroxytryptamine
- From:
Chinese Journal of Neuromedicine
2023;22(10):1069-1073
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a mental disease that seriously threatens life and health, and its pathogenesis is complicated. Recent studies have found that altitude is one of the important factors leading to depression. As an important transcription factor under hypoxic condition, hypoxia-inducible factor-1 regulates acute hypoxia, and upregulates neurotrophic factor and 5-hydroxytryptamine, thus exerting antidepressant effect by promoting brain metabolism; hypoxia-inducible factor-2 regulates chronic hypoxia, promotes inflammation and aggravates depression. This article focuses on the related research on hypoxia-inducible factors and pathogenesis of high altitude depression, to further explore the pathogenesis and prevent high altitude depression.
