Role and mechanism of Schwann cells in peripheral nerve regeneration
10.3760/cma.j.cn115354-20230404-00206
- VernacularTitle:施万细胞在周围神经再生中的作用及机制
- Author:
Yi LI
1
;
Yuzhong WANG
Author Information
1. 济宁医学院临床医学院，济宁 272029
- Keywords:
Peripheral nerve injury;
Schwann cell;
Myelin sheath
- From:
Chinese Journal of Neuromedicine
2023;22(7):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have shown that Schwann cells (SCs) can effectively promote peripheral nerve regeneration under physical modulation of mechanical retraction, electricity, magnetism, light, and extracorporeal shock waves, whose neural signaling pathways involve Janus kinase/signal transduction and transcriptional activator (JAK-STAT) pathway, mitogen-activated protein kinase (MAPK) pathway, Notch pathway, and neuregulin 1 (NRG1) pathway. In this paper, we summarize the role and mechanism of SCs in peripheral nerve regeneration, as well as the therapeutic strategies based on SCs to promote peripheral nerve repair in recent years, aiming to provide references for clinical treatment of peripheral neuropathy.
