Correlations of urinary Alzheimer-associated neuronal thread protein with apolipoprotein E allele and cognitive function in patients with subjective cognitive decline, mild cognitive impairment or Alzheimer's disease
10.3760/cma.j.cn115354-20221230-00945
- VernacularTitle:阿尔茨海默病及其前期患者尿AD7c-NTP与ApoE等位基因、认知功能的关系研究
- Author:
Hongyan LI
1
;
Xianfeng YU
;
Hailiang WANG
;
Yuxia LI
Author Information
1. 首都医科大学宣武医院神经内科，北京 100053
- Keywords:
Alzheimer's disease;
Mild cognitive impairment;
Subjective cognitive decline;
Alzheimer-associated neuronal thread protein;
Apolipoprotein E;
Urine
- From:
Chinese Journal of Neuromedicine
2023;22(5):470-475
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations of urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) with apolipoprotein E (ApoE) allele and cognitive function in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and Alzheimer's disease (AD).Methods:Two hundred and fifty-nine AD patients or patients at prodromal AD stage, including SCD ( n=148), MCI ( n=65), and AD ( n=46), admitted to Department of Neurology, Xuanwu Hospital, Capital Medical University from January 2019 to January 2021, were chosen. Results of neuropsychological assessment, ApoE alleles and urinary AD7c-NTP level were collected in all subjects. Correlations of AD7c-NTP with grading of ApoE alleles and neuropsychological assessment results were analyzed by Spearman's rank correlation. Results:Urinary AD7c-NTP level in AD group was significantly higher than that in MCI group and SCD group ( P<0.05). ApoE genotype test showed that, in these 259 subjects, 24 had ApoE genotype grading 1, 150 had APOE genotype grading 2, 10 had APOE genotype grading 3, and 75 had APOE genotype grading 4; compared with patients with ApoE genotype grading 1 and 2, patients with ApoE genotype grading 4 had significantly increased urinary AD7c-NTP level ( P<0.05). Correlation analysis showed that urine AD7c-NTP level was positively correlated with ApoE genotype grading ( r s=0.264, P<0.001). Urinary AD7c-NTP level was negatively correlated with scores of Montreal cognitive assessment, auditory verbal learning test-N5, animal verbal fluency test and Boston naming test ( P<0.05), and positively correlated with shape trails tests-A and shape trails tests-B scores ( P<0.05). Conclusion:In AD patients or patients at prodromal AD stage, the higher the urinary AD7c-NTP level, the higher the ApoE genotype grading and the greater the decline in cognitive function.
