Role of mesenchymal stem cells in regulating α-synuclein microenvironment in Parkinson's disease
10.3760/cma.j.cn115354-20220707-00476
- VernacularTitle:间充质干细胞调节帕金森病中α-突触核蛋白相关微环境作用的研究进展
- Author:
Weiling DONG
1
;
Hui YUAN
Author Information
1. 山东第一医科大学第二附属医院神经内科，泰安 276300
- Keywords:
Parkinson's disease;
Mesenchymal stem cell;
α-synuclein;
Microenvironment
- From:
Chinese Journal of Neuromedicine
2022;21(12):1276-1280
- CountryChina
- Language:Chinese
-
Abstract:
The α-synuclein, the main component of Lewy bodies, is closely related to Parkinson's disease (PD) development. Mesenchymal stem cell transplantation has shown a remarkable prospect in PD treatment, and indirect regulation of abnormal α-synuclein-related microenvironment is a key part of its neuroprotective mechanism, but the specific mechanism is extremely complex and remains unclear. We briefly discuss the roles of mesenchymal stem cells in regulating the abnormal α-synuclein related microenvironment by enhancing α-synuclein autophagy, increasing hydrolysis of α-Syn aggregates, and inhibiting α-synuclein intercellular transmission, to help in mesenchymal stem cell transplantation for PD treatment.
