Recent advance in pathogenesis and treatment of depression related hyperalgesia
	    		
		   		
		   			
		   		
	    	
    	 
    	10.3760/cma.j.cn115354-20220709-00480
   		
        
        	
        		- VernacularTitle:抑郁症伴发痛觉过敏的发病机制及治疗研究进展
 
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Yibao ZHANG
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Guangfen ZHANG
			        		
			        		;
		        		
		        		
		        		
			        		Jianjun YANG
			        		
			        		;
		        		
		        		
		        		
			        		Zhiqiang ZHOU
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. 南京医科大学金陵临床医学院(东部战区总医院)麻醉科,南京 210002
			        		
		        		
	        		
        		 
        	
        	
        	
        	
        		- Keywords:
        			
	        			
	        				
	        				
			        		
				        		Depression;
			        		
			        		
			        		
				        		Hyperalgesia;
			        		
			        		
			        		
				        		Pathogenesis
			        		
			        		
	        			
        			
        		
 
        	
            
            
            	- From:
	            		
	            			Chinese Journal of Neuromedicine
	            		
	            		 2022;21(9):940-944
	            	
            	
 
            
            
            	- CountryChina
 
            
            
            	- Language:Chinese
 
            
            
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		        	Abstract:
			       	
			       		
				        
				        	Depression is one of the major types of psychiatric disorders, and often accompanies hyperalgesia except for mood alteration. At present, the mechanism of depression related hyperalgesia is mainly focused on monoamines, inflammatory cytokines, brain-derived neurotrophic factors and related neural circuits. At present, there is still a lack of specific treatment drugs for depression related hyperalgesia; and psychological therapy and traditional Chinese medicine therapy can play active auxiliary roles. In this review, the latest research progress of the above contents are noted to provide references for research and prevention of this disease.