Significance of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 1 in early clinical diagnosis of post-neurosurgical bacterial meningitis
10.3760/cma.j.cn115354-20210107-00014
- VernacularTitle:脑脊液strem-1水平在神经外科术后细菌性脑膜炎早期临床诊断中的意义
- Author:
Jiabei CHEN
1
;
Song FANG
;
Bin LI
;
Guoqiang TANG
Author Information
1. 郴州市第一人民医院神经外科 423000
- Keywords:
Soluble triggering receptor expressed on myeloid cells 1;
Neurosurgery;
Bacterial meningitis
- From:
Chinese Journal of Neuromedicine
2021;20(10):1027-1031
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the significance of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 1 (strem-1) in early clinical diagnosis of post-neurosurgical bacterial meningitis (PNBM).Methods:Twenty-seven patients with PNBM (5 had etiology diagnosis and 22 had clinical diagnosis), accepted surgery in our hospital from October 2017 to October 2019, were chosen in our study; 40 patients with post-neurosurgical aseptic meningitis (PNAM) accepted surgery at the same period were selected as controls. Levels of strem-1 in the cerebrospinal fluid of patients from PNBM and PNAM groups were detected by enzyme linked immunosorbent assay (ELISA). The clinical data of these patients were compared; the differences of cerebrospinal fluid markers and strem-1 levels were compared between the two groups. Receiver operating characteristic (ROC) curve was used to evaluate the diagnosis significance of CSF markers and strem-1 in PNBM.Results:Patients with etiology diagnosed PNBM had significantly higher count of white blood cells (WBCs), levels of protein, lactic acid and strem-1 in the cerebrospinal fluid, and statistically lower glucose level than PNAM patients ( P<0.05). Patients with clinically diagnosed PNBM had significantly higher levels of protein, lactic acid and strem-1 in the cerebrospinal fluid than PNAM patients ( P<0.05). The area under the ROC curve of WBCs count, levels of protein, glucose, lactic acid and strem-1 in the cerebrospinal fluid for predicting clinically diagnosed PNBM were 0.703, 0.661, 0.644, 0.810 and 0.894, respectively; the cut-off value of strem-1 level in predicting clinically diagnosed PNBM was 42.5 ng/L, with specificity of 85% and sensitivity of 81.8%. Conclusion:The level of strem-1 in cerebrospinal fluid has certain value in early clinical diagnosis of neurosurgical PNBM.
