Correlations of SOX17 gene single nucleotide polymorphisms with sporadic intracranial aneurysm in patients from Anhui province
10.3760/cma.j.cn115354-20210326-00201
- VernacularTitle:SOX17基因单核苷酸多态性与安徽地区散发颅内动脉瘤的相关性研究
- Author:
Lei ZHU
1
;
Chuanqing YU
;
Min XUE
;
Jie CHEN
;
Shuyang DONG
;
Guanmin HUANG
;
Yueyue CHANG
;
Mei ZHANG
Author Information
1. 安徽理工大学第一附属医院（淮南市第一人民医院）神经内科 232007
- Keywords:
Intracranial aneurysm;
SOX17;
Single nucleotide polymorphism;
Genotype;
Allele
- From:
Chinese Journal of Neuromedicine
2021;20(8):776-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlations of SOX17 gene polymorphisms at the rs1072737, rs9298506 and rs10958409 loci with sporadic intracranial aneurysm (IA) in patients from Anhui province. Methods:A case-control study was performed on 162 patients with sporadic ruptured IA admitted to our hospital from January 2017 to December 2020 and 182 age-matched controls from Inpatient or physical examination center at the same time-period. The genotype and allele frequencies of SOX17 gene at the rs1072737, rs9298506 and rs10958409 loci between the 2 groups were analyzed and compared to determine the influence of different genotypes and alleles in IA. According to gender, the subjects were divided into male and female subgroups; according to rupture of IA, the subjects were divided into ruptured and un-ruptured subgroups; the risk factors and protective factors for IA in these subgroups were verified. Results:There was no significant difference in genotype distributions at rs10958409 locus between the two groups ( P>0.05). The results of multivariate Logistic regression analysis indicated that GG+GT genotype ( OR=0.913, 95%CI: 0.845-0.990, P=0.031) and allele G ( OR=0.805, 95%CI: 0.718-0.932, P=0.029) at rs1072737 locus were independent protective factors for IA, and GG+AG genotype ( OR=1.043, 95%CI: 1.008-1.084, P=0.011) and allele G ( OR=1.003, 95%CI: 1.001-1.007, P=0.023) at rs9298506 locus were independent risk factors for IA. GG+GT genotype and G allele at rs1072737 locus were still risk factors for IA in both males and females ( P<0.05), while GG+AG genotype and G allele at rs9298506 locus were still protective factors for IA in both males and females ( P<0.05). There was no significant difference in in genotype distributions at rs1072737 and rs9298506 loci between ruptured subgroup and un-ruptured subgroup ( P>0.05). Conclusions:In Anhui province, GG+GT genotype (allele G) carriers in SOX17 gene at rs1072737 locus have a relatively low risk of IA, while GG+AG genotype (allele G) carriers in SOX17 gene at rs9298506 locus have a relatively high risk of IA. There is no correlation of SOX17 gene polymorphisms at rs1072737 and RS9298506 loci with rupture of IA.
