Recent advance in pathogenesis of aquaporin-4 immunoglobulin G positive neuromyelitis optica spectrum disorder
10.3760/cma.j.cn115354-20201127-00925
- VernacularTitle:水通道蛋白4抗体阳性视神经脊髓炎谱系疾病的发病机制研究进展
- Author:
Jing LI
1
;
Jialing LIU
;
Yongzhong LIN
Author Information
1. 大连医科大学附属第二医院神经内科，大连 116023
- Keywords:
Neuromyelitis optica spectrum disorder;
Aquaporin-4;
Aquaporin-4 immunoglobulin G
- From:
Chinese Journal of Neuromedicine
2021;20(4):422-426
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system inflammatory disease characterized by aquaporin-4 immunoglobulin G (AQP4-IgG). The core clinical manifestations include acute myelitis, optic neuritis and area postrema syndrome. AQP4-IgG-positive NMOSD patients have severe symptoms, frequent relapses, less complete recovery and early disability. In recent years, AQP4-IgG-positive NMOSD has gradually been recognized, but its exact mechanism is still unclear. This paper reviews the recent advance in pathogenesis of AQP4-IgG positive NMOSD.
