Recent advances in blood biomarkers of post-stroke cognitive impairment

VernacularTitle:脑卒中后认知障碍血液学生物标志物的研究进展
Author: Hongzhou ZUO ¹ ; Kun CHU ; Ling TANG ; Sisi ZHAO ; Xiaoqing BU
Author Information

1. 重庆医科大学公共卫生与管理学院流行病学教研室，重庆　400016
Keywords: stroke; Cognitive impairment; Biomarker; Blood
From: Chinese Journal of Neuromedicine 2021;20(4):412-416
CountryChina
Language:Chinese
Abstract: Post-stroke cognitive impairment (PSCI) is a kind of common complications after stroke, which seriously affects the functional recovery. The diagnosis of PSCI mainly depends on imaging measures and scale assessments at present, but these methods have some limitations. Blood samples are relatively convenient to collect for biomarker detection, and uitable for practical application in a clinical setting. Along with a remarkable development of molecular biology, increasing studies have shown that biomarkers of neuroinjury, inflammation and oxidative stress have played important roles in the development and progression of PSCI. Herein we review the progress and pathogenesis of blood biomarkers for PSCI, and the application of these biomarkers in prevention and early diagnosis of PSCI.