TREVO stent thrombotomy combined with tirofiban in patients with acute large-artery occlusion of the anterior circulation
10.3760/cma.j.cn115354-20200920-00751
- VernacularTitle:TREVO支架取栓联合替罗非班在急性前循环大血管闭塞患者中的应用分析
- Author:
Yanping WANG
1
;
Changming WEN
;
Baochao ZHANG
;
Gongling WEN
;
Jun SUN
;
Yifeng LIU
;
Ning WANG
;
Xiaoyu QIAN
Author Information
1. 南阳市中心医院神经内科 473000
- Keywords:
Cerebral infarction;
Large-artery occlusion;
Mechanical hrombectomy;
Tirofiban
- From:
Chinese Journal of Neuromedicine
2021;20(1):29-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical effect of TREVO stent thrombectomy combined with tirofiban on patients with acute large-artery occlusion of the anterior circulation.Methods:Seventy-two patients with acute large-artery occlusion of the anterior circulation accepted thrombectomy in our hospital from November 2016 to May 2020 were divided into two groups according to different treatment methods: 35 patients in the control group were treated with TREVO stent thrombectomy, and 37 patients in the treatment group were treated with TREVO stent thrombectomy combined with tirofiban via intra-variceal injection. The success rate of recanalization, specific conditions of thrombolysis, improvement degrees of nerve defect, coagulation function, prognoses 90 d after thrombectomy, and complications were compared between the two groups.Results:The success rate of postoperative vascular recanalization in the treatment group and control group was 91.89% (34/37) and 88.57% (31/35), respectively, without statistically significant difference ( P>0.05). The time and times of thrombotomy in the treatment group were significantly shorter/smaller than those in the control group (P<0.05). The National Institute of Health stroke scale (NIHSS) scores of patients from the treatment group 14 d after thrombectomy were significantly lower than those of the control group ( P<0.05). The postoperative thrombin time, prothrombin time, and activated partial thrombin time of the treatment group were significantly longer than those of the control group ( P<0.05). The good prognosis rate of patients in the treatment group and control group 90 d after thrombectomy was 86.49% (32/37) and 60.0% (21/35), with significant differences ( P<0.05); and the incidence of complications was 8.11% (3/37) and 14.29% (5/35), without significant differences ( P>0.05). Conclusion:TREVO stent thrombectomy combined with tirofiban has a significant effect on treatment of acute large-artery occlusion of the anterior circulation, enjoying high safety.
