Recent advances in role of TAR DNA-binding protein 43 in pathogenesis of Alzheimer's disease
10.3760/cma.j.issn.1671-8925.2019.01.017
- VernacularTitle:TDP-43在阿尔茨海默病发病机制中的作用研究
- Author:
Yongjian ZHOU
1
;
Nanqu HUANG
;
Yong LUO
Author Information
1. 遵义医科大学第三附属医院神经内科
- Keywords:
TAR DNA-binding protein 43;
Alzheimer's disease;
Cognitive dysfunction
- From:
Chinese Journal of Neuromedicine
2019;18(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease involving a variety of pathogenic factors.Studies have shown that TAR DNA-binding protein 43 (TDP-43) may cause AD pathological changes and induce cognitive dysfunction by increasing Aβ abnormal deposition,promoting Tau hyperphosphorylation,triggering mitochondrial dysfunction,and aggravating neuroinflammation.This paper reviews the important role of TDP-43 in the pathogenesis of AD.
