Clinical features of anti-γ-aminobutyric acid B receptor encephalitis
10.3760/cma.j.issn.1671-8925.2017.09.013
- VernacularTitle:抗γ-氨基丁酸B受体脑炎临床特点分析
- Author:
Cancan WANG
1
;
Yuanxing ZHANG
;
Huili YANG
;
Yingying WU
;
Yingying SHI
;
Xinya GAO
;
Changshui XU
;
Jianhua ZHAO
;
Yamei HU
;
Xiaohong SHI
;
Jiewen ZHANG
Author Information
1. 郑州大学人民医院神经内科
- Keywords:
Gamma-aminobutyric acid;
Encephalitis;
Epilepsy;
Small cell lung cancer
- From:
Chinese Journal of Neuromedicine
2017;16(9):938-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics,imaging manifestations and prognoses of anti-GABAB receptor antibodies encephalitis.Methods The clinical manifestations,laboratory findings and radiological data of 13 patients with anti-GABAB receptor encephalitis,admitted to our hospital from September 2015 to March 2017,were retrospectively analyzed.Modified Rankin scale (mRs) was performed to evaluate the prognoses (good prognosis:mRs scores ＜ 2;poor prognosis mRs scores≥3).Results These 13 patients had an average age of 58 years (ranged 49-76 years) with a male to female ratio of 12:1.The major clinical features,including epileptic seizure,were found in 12 patients,psychiatric symptoms in 11 patients,cognitive disorder in 7 patients,and disturbance of consciousness in 4 patients.Brain MR imaging showed abnormal signal in 5 patients:4 were located in the hippocampus and amygdaloid,and one in the pons and left temporal lobe.Five patients showed abnormalities in PET-CT,including 4 with temporal hypermetabolism and 1 with cortical hypometabolism.Chest CT showed lung occupying lesions in 4 patients,of which 2 patients were diagnosed as having small cell lung cancer (SCLC) by pathological examination.Ten patients received immunomodulatory therapy,and three were with supportive care.After the average of 8 months of follow-up,7 patients had good prognosis,5 patients had poor prognosis and one patient lost of follow up.Conclusions Anti-GABAB receptor encephalitis frequently occurs in elderly male subjects and the main characteristic includes prominent refractory epilepsy and shows neurological improvement on immunotherapy.It can accompany by SCLC and have a relatively poor prognosis.
