Association of iron-related gene polymorphisms with Parkinson's disease
10.3760/cma.j.issn.1671-8925.2015.07.011
- VernacularTitle:铁相关基因多态性与帕金森病的关联分析
- Author:
Ying XIAO
1
;
Benshu ZHANG
;
Qi LI
;
Xiaowen LI
Author Information
1. 天津医科大学总医院神经内科
- Keywords:
Parkinson's disease;
Genotype;
Polymorphism
- From:
Chinese Journal of Neuromedicine
2015;14(7):700-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphisms of two iron-related genes Transferrin (Tf) 258G/S and Transferrin receptor (TfR) 82S/G and Parkinson's disease (PD) in north and northwest China.Methods Polymerase chain reaction and restrict on fragment length polymorphism (PCR-RFLP) was used to analyze the genotypes and allele frequency distributions of Tf258G/S and TfR 82S/G in 61 north china PD patient group and 70 randomly selected locally healthy control subjects,and in 56 northwest China PD patient group and 70 randomly selected locally healthy control subjects.Results (1) In allelic and genotypic distributions of Tf258 G/S,the allele G and genotype GS in two PD patient groups were both significantly higher than those in corresponding controls (P＜0.05),but there was no significant difference between the two PD patient groups,or between the two controls (P＞0.05).(2) There were no significant differences in allelic and genotypic distributions of TfR 82S/G between the two PD patient groups,or between the two controls (P＞0.05).Conclusions There might be association of Tf 258 G/S gene polymorphism with north and northwest China PD patients;the allele G and genotype GS might increase susceptibility to PD.No association of TfR 82S/G gene polymorphism with north and northwest China PD patients is noted.
