Effect of valproate sodium on genito-endocrine secretion in maidens with epilepsy

VernacularTitle:丙戊酸钠对少女癫痫患者性激素的影响
Author: Jun LIU ¹ ; Fu-Qi XING ; Yu SHI ; Gui-Lan WANG ; Tao WU ; Jian-Ping ZHU
Author Information

1. 南方医科大学南方医院生殖中心
Keywords: Epilepsy; Female patient; Valproate sodium; Testosterone; Estradiol; Follicle-stimulating hormone
From: Chinese Journal of Neuromedicine 2012;11(10):989-991
CountryChina
Language:Chinese
Abstract: Objective To analyze the influence of anti-epileptic drug valproate sodium (VPA)on the level of sex hormone in maidens with epilepsy.Methods Forty-six maidens with epilepsy aged from 8 to 15 years,collected in our hospital from September 2009 to October 2011 and received VPA treatment for 12 months,were chosen in our study.The levels of testosterone,estradiol (E2) and follicle-stimulating hormone (FSH) were surveyed before medication and 3,6,12 months after medication.Results The levels of E2 and FSH in maidens with epilepsy during the 12 months of VPA medication showed no significant difference as compared with those before treatment (P＞0.05); but the level of testosterone 12 months after medication (0.5±0.4 ng/mL) decreased compared with that before treatment (0.8 ±0.3 ng/mL) and 3 months after medication (0.8±0.3 ng/mL) (P＜0.05).Conclusion VPA has little effect on sex hormone level of maidens with epilepsy,and VPA is the best solution of treating maidens with epilepsy.