Potent protective effect of ferulic acid on glutamate-induced neurotoxicity in adult mice
10.3760/cma.j.issn.1671-8925.2008.06.014
- VernacularTitle:阿魏酸钠对谷氨酸盐诱导的成年小鼠神经毒性的保护作用
- Author:
Yong-Ping ZHANG
1
;
Li-Jian YU
;
Run-Di MA
;
Li BAO
;
Rong ZENG
;
Juan-Zhi FANG
;
Xiao-Yu ZHANG
;
Ting-Xi YU
Author Information
1. 广东海洋大学
- Keywords:
Excitatory amino acids;
Neurotoxicity;
Neuroprotection;
Ferulic acid
- From:
Chinese Journal of Neuromedicine
2008;7(6):596-599,606
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate a possible protective effect of sodium ferulate (SF) on monosodium glutamate (MSG)-induced neurotoxicity in adult mice. Methods Sixty mice were randomly divided into control, SF, MSG, and MSG+SF [20,40,80mg/(kg·d)] groups, n=10. The animals in MSG group received intragastric (ig) administration of MSG (2.0g/(kg·d)], the animals in the MSG+SF groups received simultaneously ig administration of MSG [2.0 g/(kg·d)] and intraperitoneal (ip) administration of SF [20,40,80mg/(kg·d)], the animals in SF group received ip administration of SF [40mg/ (kg·d)], and the animals in control group received ig and ip administration of normal saline, respectively, once-daily for 10d. On day 1 after the last ig administration of MSG or (and) SF the behavioural tests (test of Y-maze discrimination learning and open field test) were performed, and on day 4 after the treatment of MSG or (and) SF the histopathology of the animal brains was studied to analyze the MSG-induced functional and morphological changes and the possible protective effect of SF. Results The correct responses of Y-maze test on day 6 after the last administration of MSG and/or SF in MSG-treated group (13.83/20) were significantly less than those in control (16.42/20)(P<0.01), and those in MSG[2.0g/(kg·d)]+SF[40mg/(kg·d)]-treated mice (16.30/20) were close to those in control (P>0.05). Examination of histopathology displayed MSG-treated hippocampal lesions characterized by intracellular edema, degeneration and necrosis of neurons, and hyperplasia, and the hippocampal lesion did not appear in the MSG [2.0g/(kg·d)]+SF[40mg/(kg·d)]-treated mice. Conclusions SF partially countered the behavior disorders and hippocampal lesions induced by MSG; therefor, SF has a potent neuroprotection against MSG-induced neurotoxicity in adult mice.
