Relationship between leukoaraiosis and obstructive sleep apnea/hypopnea syndrome in elderly patients

VernacularTitle:老年人阻塞性睡眠呼吸暂停综合征与脑白质疏松的关系
Author: Li-Fen RAO ¹ ; Jian-Wei MO ; Qin-Wei ZHENG ; Qiong OU
Author Information

1. 广东省人民医院
Keywords: Leukoamiosis; Sleep apnea,olbstructive; Aged
From: Chinese Journal of Neuromedicine 2008;7(3):308-310
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between the leukoaraiosis (LA) and obstructive sleep apnea/hypopnea syndrome(OSAHS)in the elderly. Methods 169 cases of OSAHS diagnosed by polysomnogram (PSG) underwent brain MRI to evaluate the incidence and degree of LA and to explore the relationship between LA and OSAHS in the elderly. Results LA was found in 145 (85.80%) of 169 OSAHS cases, and rdmong them, mild LA in 27 cases (15.98%), moderate in 65 (38.46%) and severe in 53 (31.36%). There was a significant correlation of LA with age, oxygen desaturation index,MSaO2 sleep time spent when SaO2＜90%,apnea hyponea index(AHI)(P＜0.05).By multivariate regression analyses, age and oxygen desaturation index were the most vital effective factors for LA. Conclusions With the increase of patients'age and oxygen desaturation index,LA becomes more common and aggravated. Appropriate interventive treatment for OSAHS will be able to ameliorate the LA-induced cognitive dysfunction.