Impact of dexmedetomidine on apoptosis of rat hippocampal neurons induced by Aβ1-42 via MAPK/STAT3 pathway
10.19845/j.cnki.zfysjjbzz.2023.0028
- VernacularTitle:右美托咪定通过MAPK/STAT3通路对AD大鼠海马神经元凋亡的影响
- Author:
Miao ZHANG
1
;
Yanhai DONG
1
Author Information
1. Department of Anesthesiology,Baoding Second Hospital,Baoding 071000,China
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
MAPK/STAT3 pathway;
Aβ1-42;
Hippocampal neurons
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(2):113-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of dexmedetomidine (Dex) on the apoptosis of rat hippocampal neurons induced by β-amyloid (Aβ) 1-42 via mitogen-activated protein kinase (MAPK)/signal transduction and transcriptional activators 3 (STAT3) pathway. Metuods The patients were randomly divided into sham operation group,Aβ1-42、Dex(Dex-L)、Dex(Dex-H)、Dex-H+Anisomycin、Dex-H+colivelin group.The experimental observation was carried out after different treatment of administration.Results In the Aβ1-42 group,the neuronal structure of the hippocampus of rats in the Aβ1-42 group was lost,the cell body morphology was abnormal,and the Aβ deposition was severe,the escape latency,the levels of inflammatory factors (IL-1β,IL-6,TNF-α),the number of apoptotic cells,the expressions of p-p38 MAPK/p38 MAPK,p-STAT3/STAT3,and cleaved caspase-3 were unusually higher than those in the sham operation group,the times of crossing the original platform and the expression of Bcl-2 were unusually lower (P<0.05);the above indicators could be reversed after intervention with different doses of Dex (P<0.05);MAPK pathway activators and STAT3 activators could alleviate the protective effect of Dex on AD rats (P<0.05). Conclusion Dex can reduce the levels of inflammatory factors and Aβ deposition to reduce cell damage and apoptosis,and protect rat hippocampal neurons,which may be related to the inhibition of MAPK/STAT3 pathway.
- Full text:2024061722395995410Impact of dexmedetomidine on apoptosis of rat hippocampal neurons induced by Aβ1-42 via MAPK_STAT3 pathway.pdf
