Advances in the study of Aβ oligomers and Alzheimer's disease
10.19845/j.cnki.zfysjjbzz.2023.0136
- VernacularTitle:Aβ寡聚体与阿尔茨海默病研究进展
- Author:
Guoqing WANG
1
;
Yunpeng CAO
1
Author Information
1. Department of Neurology,The First Hospital of China Medical University,Shenyang 110001,China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Amyloid;
Aβ oligomers;
Neurotoxicity
- From:
Journal of Apoplexy and Nervous Diseases
2023;40(7):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disease with memory impairment as the main manifestation. With the development of an aging society,the incidence of AD is on the rise,bringing a huge social and economic burden. In recent years,the classical amyloid cascade hypothesis in the pathogenesis of AD has been challenged,and the toxic effects of Aβ oligomers (AβOs) have been consistently recognized,which may be a trigger for the pathogenesis of AD. The specific source,structure,and pathogenic mechanism of Aβ oligomers are not fully understood. It is possible that different types of oligomers are not consistent in pathogenicity and toxicity,and their mechanisms of action are different. This article reviews the recent understanding of Aβ oligomers,as well as their structural characteristics and pathogenic effects,to better understand the relationship between Aβ oligomers and AD,and provide possible directions for future research.
- Full text:2024061611100761778Aβ寡聚体与阿尔茨海默病研究进展.pdf
