Research advances in the pyroptosis signaling pathway after intracerebral hemorrhage
- VernacularTitle:脑出血后细胞焦亡信号通路研究
- Author:
Zhe WU
1
;
Wei ZOU
1
Author Information
- Publication Type:Journal Article
- Keywords: Intracerebral hemorrhage; Pyroptosis; Signaling pathways
- From: Journal of Apoplexy and Nervous Diseases 2023;40(9):851-858
- CountryChina
- Language:Chinese
- Abstract: Pyroptosis is an important mechanism leading to secondary brain injury （SBI） after intracerebral hemorrhage （ICH）， which can be classified into the inflammasome-dependent classical pyroptosis pathway and the caspase-4/5/11-dependent non-classical pyroptosis pathway. GSDMD and GSDME of the gasdermin family are the key effectors of pyroptosis and bind to lipids on cell membrane to induce the formation of membrane pore. Interleukin-1β/-18 is a downstream inflammatory factor that mediates inflammatory injury after pyroptosis. This article reviews the key proteins in the pyroptosis pathway and the mechanism of action of the pyroptosis signaling pathway after ICH.
- Full text:2024061416004103047脑出血后细胞焦亡信号通路研究.pdf
