Integrated Pharmacology of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20232401
- VernacularTitle:整合药理学在中医药现代研究的若干进展
- Author:
Shanshan LI
1
;
Weijie LI
1
;
Ping WANG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
integrated pharmacology;
Chinese medicinal formula;
biological connotation of syndrome;
safety and efficacy;
quality control;
material basis of pharmacodynamic effects
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(14):270-278
- CountryChina
- Language:Chinese
-
Abstract:
Chinese medicinal formulae （CMF）， as the main form and means of clinical treatment， are a key link in traditional Chinese medicine （TCM） theory and clinical practice. Exploring the relationship between the chemical substances of CMF and the life activities of the body， as well as their complex interaction patterns， is one of the key issues in modern research of TCM. However， due to the complexity of chemical composition and the diversity of biological effects， evidence remains to be mined for the chain involving chemical composition， in vivo process， and pharmacological activity of CMF， which results in serious fragmentation of related studies. Integrated pharmacology is proposed as an effective strategy for analyzing the molecular interactions of complex systems in TCM. Particularly， it reflects the new trend of using new technologies such as the Internet， big data， and artificial intelligence to drive the development of complex systems in TCM in the context of the fourth wave represented by the biotechnology revolution. This provides a practical and feasible approach for systematically revealing the interaction， integration patterns， and principles of action between multi-component drugs and the body. This article reviews the emergence and development， research ideas， key technologies， and applications of integrated pharmacology of TCM， providing support for explaining the scientific connotation of TCM theory and the scientific value of original thinking of TCM， inheriting the experience of famous doctors， and facilitating the quality control， mechanism explanation， and new medicine development of TCM.
