Research progress on the role of NMDA receptors in migraine
- VernacularTitle:NMDA受体在偏头痛中作用的研究进展
- Author:
Yanan HUANG
1
;
Yake LIN
1
;
Tingting SUN
1
;
Yonghui PAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Migraine; NMDA receptor; NMDA receptor antagonist; Cortical spreading depression
- From: Journal of Apoplexy and Nervous Diseases 2023;40(12):1079-1083
- CountryChina
- Language:Chinese
- Abstract: NmethylD-aspartate （NMDA） receptors are ionotropic glutamate receptors that are widely expressed in the central nervous system.Through mediating Ca2+ influx for excitatory synaptic transmission，NMDA receptors play an important role in synaptic plasticity，learning，and memory.Migraine is a common primary headache that brings serious life and mental burdens to patients because of frequent attacks.The pathogenesis of migraine is still unclear.Glutamate and NMDA receptors have been demonstrated to be closely related to the occurrence of migraine.This paper reviews progress on the association of NMDA receptors with migraine and the use of NMDA receptor antagonists for the prevention and treatment of migraine，aiming to provide a reference for the pathogenesis and drug treatment of migraine.
- Full text:2024061221282509042Research progress on the role of NMDA receptors in migraine.pdf
