Research Progress on O-GLcNAc Glycosylation Modification in Neurodegenerative Diseases
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240515.002
- VernacularTitle:O连接N-乙酰葡萄糖胺糖基化修饰在神经退行性疾病中的研究进展
- Author:
Ting YU
1
;
Haijun LIU
Author Information
1. 遵义医科大学附属医院神经内科,贵州 遵义 563000;遵义医科大学研究生院,贵州 遵义 563000
- Keywords:
O-GlcNAc glycosylation;
neurodegeneration;
OGT;
OGA;
glycosylation modification
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2024;45(3):370-376
- CountryChina
- Language:Chinese
-
Abstract:
O-linked N-acetylglucosamine glycosylation(O-GlcNAcylation)is a protein post-translational protein formed by O-linked acetylglucosamine and serine/threonine residues on intracellular proteins.O-GlcNAc glycosylation modification is ubiquitous in the brain and is closely related to transcription,translation and protein homeostasis.O-GlcNAc glycosylation modification is involved in the occurrence and development of various neurological degenerative dis-eases,but its regulatory mechanism remains unclear.This paper reviews the relationship between O-GlcNAc glycosylation modification and neurological degenerative diseases.
